Tirzepatide vs Semaglutide
Both Tirzepatide and Semaglutide are FDA-approved GLP-1 receptor agonists that support weight loss and improve metabolic health. But they have important differences.
Mechanism of Action
Tirzepatide (Mounjaro® / Zepbound®): Dual GIP + GLP-1 receptor agonist. Targets two hormones to regulate blood sugar, appetite, and metabolism.
Semaglutide (Ozempic® / Wegovy®): GLP-1 receptor agonist. Mimics the GLP-1 hormone to regulate blood sugar and reduce appetite.
Weight Loss Results
- Tirzepatide: Up to 20-25% average total body weight loss
- Semaglutide: Up to 15-17% average total body weight loss
Dosing
- Tirzepatide: Once weekly injection. Dose options from 2.5 mg to 15 mg
- Semaglutide: Once weekly injection. Dose options from 0.25 mg to 2.4 mg
Which Is Right For You?
Tirzepatide may be right if:
- You want maximum weight loss potential
- You need more appetite and blood sugar control
- You're looking for dual-action hormone support
Semaglutide may be right if:
- You prefer a well-established option
- You have cardiovascular concerns
- You want a proven, long-term solution
Both medications, when combined with proper diet and exercise, can lead to transformative results. Book a consultation to discuss which option is best for you.